Buy Oxycontin Online
Buy Oxycontin Online, Oxycontin 40mg is a semisynthetic opioid synthesized from thebaine, an opioid alkaloid found in the Persian poppy, and one of the many alkaloids found in the opium poppy.
It is a moderately potent opioid pain medication, generally indicated for relief of moderate to severe pain.
Experts are divided regarding use for non-cancer-related chronic pain, as most opioids have great potential for dependence and have also been alleged to create paradoxical pain sensitivity.
it is available as a controlled-release tablet, intended to be taken every 12 hours.
In the United States, oxycodone is only approved for oral use, available as tablets and oral solutions.
In Spain, the Netherlands and the United Kingdom, oxycodone is also approved for intravenous (IV) and intramuscular (IM) use.
Main side effects of Oxycontin 40mg
Serious side effects of Oxycontin include reduced sensitivity to pain (beyond the pain the drug is taken to reduce), euphoria, anxiolysis, feelings of relaxation, and respiratory depression.
Common side effects of Oxycontin include constipation , nausea , vomiting , somnolence , dizziness , itching , dry mouth , and sweating .
Less common side effects include loss of appetite, nervousness, abdominal pain, diarrhea, urine retention, dyspnea, and hiccups.
In high doses, overdoses, or in some persons not tolerant to opioids, Oxycontin can cause shallow breathing, slowed heart rate, cold/clammy skin, pauses in breathing, low blood pressure, constricted pupils, circulatory collapse, respiratory arrest, and death.
Oxycontin overdose has also been described to cause spinal cord infarction in high doses and ischemic damage to the brain, due to prolonged hypoxia from suppressed breathing.
Oxycontin in combination with naloxone in managed-release tablets, has been formulated to both deter abuse and reduce “opioid-induced constipation.
Oxycontin is a highly selective full agonist of the μ-opioid receptor (MOR), with low affinity for the δ-opioid receptor (DOR) and κ-opioid receptor (KOR).
After Oxycontin binds to the MOR, a G protein-complex is released, which inhibits the release of neurotransmitters by the cell by reducing the amount of cAMP produced, closing calcium channels, and opening potassium channels.
Oxycontin dosing information
Usual Adult Dose for Pain:
Controlled Release (CR): 10 mg orally every 12 hours.
CR: 20 mg to 640 mg per day in patients with cancer pain.
The average total daily dose is approximately 105 mg per day. Cancer patients with severe pain may require “as needed” rescue doses of the immediate-release form of Oxycontin to supplement the controlled-release form.
Usual Geriatric Dose for Pain:
Immediate Release (IR): 2.5 mg orally every 6 hours
CR: 20 mg to 640 mg per day in patients with cancer pain. The average total daily dose is approximately 105 mg per day. Cancer patients with severe pain may require “as needed” rescue doses of the immediate-release form of Oxycontin to supplement the controlled-release form.
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