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Diazepam Actavis contains the active substance diazepam which belongs to a group of medicines called benzodiazepines.

Diazepam has anxiolytic, sedative and muscle relaxant effect. …

in the treatment of muscle spasms, including those caused by cerebral spasticity (originates in the brain).

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Description

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Buy Actavis Diazepam Online, Concomitant use of alcohol/CNS depressants
The concomitant use of diazepam with alcohol and/or CNS depressants should be avoided.

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Such concomitant use has the potential to increase the clinical effects of diazepam possibly including severe sedation,

clinically relevant respiratory and/or cardio-vascular depression (see section 4.5).

Medical history of alcohol or drug abuse
Diazepam should be used with extreme caution in patients with a history of alcohol or drug abuse.

Tolerance
Some loss of efficacy to the hypnotic effects of benzodiazepines may develop after repeated use for a few weeks.

Dependence
Treatment with diazepam can result in mental or physical dependency. The risk increases with dose and duration of treatment;

it is also greater in patients with a history of alcohol or drug abuse or in patients with marked personality disorders.

Regular monitoring in such patients is essential, routine repeat prescriptions should be avoided and treatment should be withdrawn gradually.

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Withdrawal
Once physical dependence has developed, abrupt termination of treatment will be accompanied by withdrawal symptoms.

These may consist of headaches, muscle pain, extreme anxiety, tension, restlessness, confusion and irritability.

In severe cases the following symptoms may occur: derealisation, depersonalisation, hyperacusis, numbness and tingling of the extremities,

hypersensitivity to light, noise and physical contact, hallucinations or epileptic seizures.

Rebound insomnia and anxiety: a transient syndrome whereby the symptoms that led to treatment with a benzodiazepine recur in an enhanced form,

may occur on withdrawal of treatment. It may be accompanied by other reactions including mood changes,

anxiety or sleep disturbances and restlessness. Since the risk of withdrawal phenomena/rebound phenomena is greater after abrupt discontinuation of treatment,

it is recommended that the dosage is decreased gradually.

Sudden discontinuation of treatment with diazepam in patients with epilepsy or other patients

who have had a history of seizures can result in convulsions or epileptic status.

Convulsions can also be seen following sudden discontinuation in individuals with alcohol or drug abuse.

Discontinuation should be gradual in order to minimise the risk of withdrawal symptoms.

Duration of treatment
The duration of treatment should be as short as possible (see section 4.2) depending on the indication.

The patient must be evaluated after a period of no more than 4weeks and then regularly thereafter in order to

assess the need for continued treatment, especially if the patient is free of symptoms.

In general, treatment must not last any longer than 8‑12weeks, including the tapering off process.

Extension beyond these periods should not take place without re-evalutaion of the situation.

It may be useful to inform the patient when treatment is started that it will be of limited duration and to explain precisely how the dosage will be progressively decreased.

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Moreover it is important that the patient should be aware of the possibility of rebound phenomena,

thereby minimising anxiety over such symptoms should they occur while the medicinal product is being discontinued.

There are indications that, in the case of benzodiazepines with a short duration of action, withdrawal phenomena can become manifest within the dosage interval, especially when the dosage is high.

When benzodiazepines with a long duration of action are being used it is important to warn against changing to a

a benzodiazepine with a short duration of action, as withdrawal symptoms may develop.

 

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